Top 10 Most Painful Diseases in the World

“Chronic illness is hard. Pain is hard. Isolation is hard. The financial cost is hard. Grieving is hard and necessary and sometimes takes far longer than we ever imagined.”― Cindee Snider Re, Discovering Hope: Beginning the Journey toward Hope in Chronic Illness.

The thought of any disease comes along with the painful conditions that accompany it. The extent of pain varies with each disease; Pain is tolerable in certain cases while in some others it breaks all barriers.The aim of the list is not to frighten the readers but just to make them aware of these conditions. The knowledge about pain that accompanies a disease would help you to remind time and again; “Prevention is better than cure.” Here is a list of world’s most painful diseases:

  1. Endometriosis

Endometriosis is a medical condition wherein the uterus lining outgrows and reaches the fallopian tubes and intestines. The tissue coating the womb outgrows and penetrates into the nearby organs. This disease might even lead to infertility. The pain is unbearable, especially during menstruation. There might be severe abdominal pain, weariness and depression. Endometriosis is most likely to occur anytime between 25-40 years, and the symptoms, except for pain, are generally not detectable. Ignorance about the disease and late treatment might turn out to be risky.

  1. Kidney Stones


Kidney Stones might be a familiar disease to most of you. A kidney stone is an unhealthy collection of diet-based minerals. Lifestyle changes have increased the number of people being affected by it. The kidney stones can occur either in powdered form or a big lump. One of the major reasons is dehydration, which leads to the high amount of calcium or sodium in the urine. As a result, extreme pain is triggered in the lower abdomen region.  The pain is subdued as soon as this mass is urinated. Painkillers are often prescribed by doctors.

  1. Cancer

Swedish actress Ingrid Bergman, who died of breast cancer once said, “Time is shortening. But everyday that I challenge this cancer and survive is a victory for me.” A silent killer, cancer is one of the major terminal diseases . It can affect any part of the body from brain to abdomen.

Cancer is a condition wherein the cells of a particular region start multiplying tremendously and result in the deletion of healthy cells. No proper cure or reason has been identified till now, but causes may vary from dietary habits to radiation. Treatment is equally painful. There are over 200 varieties of cancer detected till date. Early recognition might help in saving one’s life. Cancer treatment has many side effects and there are chances for the disease to recur.

  1. Arthritis

Arthritis is a condition of joints. It can occur in people of any ages from children to old. Pain in itself is the most common symptom. Arthritis can broadly be classified into two types-Osteoarthritis and Rheumatoid. Osteoarthritis happens when the tissue that connects two bones wears of, causing the two bones to rub over each other and causing the pain. Rheumatoid arthritis is a condition wherein the immune system of the body obliterates the joints, causing joint pain. No proper treatment is so far found against the disease; however, treatments usually focus on reducing the pain.

  1. Trigeminal Neuralgia

Trigemina is the largest nerve in the skull, whose function is to transmit signals from face to brain. Tumour, infection or inflammation can cause tremendous amount of pain in this nerve.  The sensation caused gives you the feel, as if the face is burning. One of the most painful conditions, trigeminal neuralgia can recur at definite intervals until the cause is completely cured. However, a permanent cure is not found until now. The chances of occurrence are more in females than males, usually in between the age of 40-60 years.

  1. Interstitial Cystitis

Does the term sound too complicated? Well, it is nothing but an inflamed bladder. Interstitial cystitis, also known as bladder pain syndrome (BPS), is a type of chronic pain that affects the bladder. Symptoms include feeling the need to urinate right away, needing to urinate often, and pain with sex Patients urinate more than 60 times and the pain causes a burning sensation in the lower abdomen and pelvic region. The cause is not known till now. Anti-inflammatory medicines are taken to reduce the pain.

  1. Cluster Headaches

Also called suicide headaches, cluster headaches cause rapid and recurring pain in the head. The disease isn’t easily identified as it is confused with a migraine. Over and over again these headaches happen around one of the eyes or one part of the head. The pain is so intolerable that it generates suicidal thoughts in the patients, mostly men. The cause of this condition is not yet known. Proper cure is also not found out till date, however, steroids, calcium-channel brokers bring aid. Nasal congestion, eye watering and eye inflammation are the other symptoms that accompany the disease. Tobacco Smoking is thought to be one major cause.

  1. Shingles

Shingle is a viral disease caused by the same virus that causes chicken pox- varicella zoster. The nerve is infected causing rashes and blisters on the skin. It is commonly seen in people who are once affected with chicken pox. The virus which becomes inactive is re-activated initiating shingles. The inactive virus becomes active due to a drop in immunity. The blisters are itchy and cause a burning sensation. Shingles is  followed by postherpetic neuralgia.

  1. Complex Regional Pain Syndrome (CRPS)

Complex regional pain syndrome is a nervous system anomaly. It often happens post-injury, wherein the neural response generates a chronic pain. The injury might not be a major one, but the pain is insufferable. Skin becomes too sensitive and smaller changes of temperature variation might ignite serious pain. Main treatments include physiotherapy and medication. If left untreated the pain unfolds to other regions as well. The pain might last for a few days to a few years; depending on the health of the person.

  1. Dercum’s Disease

Tumours are of two types-benign and malignant. Benign tumours are generally less troublesome. However, Dercum’s disease occurs when a cluster of this benign tumour is developed at different body parts. The tumour is also called lipomas. Dercum’s disease is also confused with obesity as fatty lumps are seen in the body.The reason for this is thought to be a dysfunctional nervous system.

Diseases of any kind is frightening. More often, it is a lack of awareness that leads to a critical condition of the patient.  Diagnosis at an early stage and the required treatments help you to get out of the perils of a disease. Proper medication and lifestyle helps you to prevent most of the above said diseases.